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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-19
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pubmed:abstractText |
Tissue fibrosis in systemic sclerosis (SSc) is attributed to excessive deposition of extracellular matrix components produced by fibroblasts in skin lesions. Angiotensin II (Ang II), a vasoconstrictive peptide, is reported to have profibrotic activity as a result of induction of the extracellular matrix. The aim of the present study was to examine the expression of Ang II and its type 1 (AT(1)) and type 2 (AT(2)) receptors in affected skin and dermal fibroblasts from patients with SSc and to study the role of Ang II in collagen production by SSc dermal fibroblasts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin D,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
216-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14730619-Adult,
pubmed-meshheading:14730619-Aged,
pubmed-meshheading:14730619-Angiotensin II,
pubmed-meshheading:14730619-Angiotensinogen,
pubmed-meshheading:14730619-Autocrine Communication,
pubmed-meshheading:14730619-Blotting, Western,
pubmed-meshheading:14730619-Cathepsin D,
pubmed-meshheading:14730619-Cells, Cultured,
pubmed-meshheading:14730619-Extracellular Matrix,
pubmed-meshheading:14730619-Female,
pubmed-meshheading:14730619-Fibroblasts,
pubmed-meshheading:14730619-Fibrosis,
pubmed-meshheading:14730619-Gene Expression,
pubmed-meshheading:14730619-Humans,
pubmed-meshheading:14730619-Immunohistochemistry,
pubmed-meshheading:14730619-Male,
pubmed-meshheading:14730619-Middle Aged,
pubmed-meshheading:14730619-Procollagen,
pubmed-meshheading:14730619-RNA, Messenger,
pubmed-meshheading:14730619-Receptor, Angiotensin, Type 1,
pubmed-meshheading:14730619-Scleroderma, Systemic,
pubmed-meshheading:14730619-Skin,
pubmed-meshheading:14730619-Transforming Growth Factor beta,
pubmed-meshheading:14730619-Transforming Growth Factor beta1
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pubmed:year |
2004
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pubmed:articleTitle |
Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors.
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pubmed:affiliation |
Tokyo Women's Medical University School of Medicine, Tokyo, Japan. y-kawa@ior.twmu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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