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rdf:type |
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lifeskim:mentions |
umls-concept:C0018270,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0025932,
umls-concept:C0026336,
umls-concept:C0027627,
umls-concept:C0031715,
umls-concept:C0071253,
umls-concept:C0086418,
umls-concept:C0235974,
umls-concept:C0392756,
umls-concept:C0906802,
umls-concept:C0935987
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pubmed:issue |
17
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pubmed:dateCreated |
2003-12-25
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pubmed:abstractText |
We evaluated the expression of platelet-derived growth factor (PDGF) ligands and receptors in clinical specimens of human pancreatic adenocarcinomas and determined the therapeutic effect of STI571 (Gleevec), a protein tyrosine kinase inhibitor of PDGF receptor (PDGFR), on human pancreatic carcinoma cells growing in the pancreas and liver of nude mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor A,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor BB
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6534-44
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14695158-Adenocarcinoma,
pubmed-meshheading:14695158-Animals,
pubmed-meshheading:14695158-Antigens, CD31,
pubmed-meshheading:14695158-Antineoplastic Agents,
pubmed-meshheading:14695158-Blotting, Western,
pubmed-meshheading:14695158-Carcinoma,
pubmed-meshheading:14695158-Cell Division,
pubmed-meshheading:14695158-Cell Line, Tumor,
pubmed-meshheading:14695158-Humans,
pubmed-meshheading:14695158-Immunohistochemistry,
pubmed-meshheading:14695158-In Situ Nick-End Labeling,
pubmed-meshheading:14695158-Ligands,
pubmed-meshheading:14695158-Mice,
pubmed-meshheading:14695158-Mice, Nude,
pubmed-meshheading:14695158-Microscopy, Fluorescence,
pubmed-meshheading:14695158-Neoplasm Metastasis,
pubmed-meshheading:14695158-Pancreatic Neoplasms,
pubmed-meshheading:14695158-Phosphorylation,
pubmed-meshheading:14695158-Piperazines,
pubmed-meshheading:14695158-Platelet-Derived Growth Factor,
pubmed-meshheading:14695158-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:14695158-Pyrimidines,
pubmed-meshheading:14695158-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:14695158-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:14695158-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.
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pubmed:affiliation |
Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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