|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2003-12-22
|
|
pubmed:abstractText |
Although B7 on APCs has a well-recognized role in T cell costimulation, little is known about the functional significance of constitutive and activation-induced B7 expression that also occurs on T cells. To analyze the role of B7 on T cells, B7-1/B7-2-deficient mice (B7 double knockout) and mice overexpressing B7-2 exclusively on T cells (B7-2 transgenic) were used as T cell donors for allogeneic transplant recipients, and graft-vs-host disease (GVHD) was assessed. B7 double-knockout T cells resulted in significant GVHD acceleration compared with wild-type T cells. Conversely, B7-2 transgenic donor T cells mediated reduced GVHD mortality compared with wild-type T cells. Data indicated that B7 expression on T cells down-regulated alloresponses through CTLA-4 ligation. This study is the first to provide definitive in vivo data illustrating the importance of T cell-associated B7 as a negative regulator of immune responses in a clinically relevant murine model of GVHD. The up-regulation of B7 on T cells may be an important component of normal immune homeostasis.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
172
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
34-9
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:14688306-Animals,
pubmed-meshheading:14688306-Antigen-Presenting Cells,
pubmed-meshheading:14688306-Antigens, CD,
pubmed-meshheading:14688306-Antigens, CD80,
pubmed-meshheading:14688306-Antigens, CD86,
pubmed-meshheading:14688306-Antigens, Differentiation,
pubmed-meshheading:14688306-Bone Marrow Transplantation,
pubmed-meshheading:14688306-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14688306-CTLA-4 Antigen,
pubmed-meshheading:14688306-Cell Communication,
pubmed-meshheading:14688306-Down-Regulation,
pubmed-meshheading:14688306-Graft vs Host Disease,
pubmed-meshheading:14688306-Ligands,
pubmed-meshheading:14688306-Lymphocyte Activation,
pubmed-meshheading:14688306-Membrane Glycoproteins,
pubmed-meshheading:14688306-Mice,
pubmed-meshheading:14688306-Mice, Inbred BALB C,
pubmed-meshheading:14688306-Mice, Inbred C57BL,
pubmed-meshheading:14688306-Mice, Transgenic,
pubmed-meshheading:14688306-Receptors, Interleukin-2,
pubmed-meshheading:14688306-T-Lymphocyte Subsets,
pubmed-meshheading:14688306-Up-Regulation
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].
|
|
pubmed:affiliation |
Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, 425 East River Road, Minneapolis, MN 55455, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
