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rdf:type |
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lifeskim:mentions |
umls-concept:C0003873,
umls-concept:C0008059,
umls-concept:C0041408,
umls-concept:C0086045,
umls-concept:C0205307,
umls-concept:C0229671,
umls-concept:C0521447,
umls-concept:C0538161,
umls-concept:C0597357,
umls-concept:C1367028,
umls-concept:C1521761
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-17
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pubmed:abstractText |
Osteoprotegerin (OPG) is a secreted member of the TNF receptor superfamily. OPG is made by osteoblastic cells and is expressed in a wide variety of cell and tissue types. It acts as a decoy receptor by binding the receptor activator of nuclear factors kB (RANKL) and preventing RANKL-induced osteoclast formation and differentiation. Numerous cytokines and hormones (TGF-beta, PTH, vitamin D, glucocorticoids and oestrogens) exert their effects on osteoclastogenesis by regulating the production of OPG.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Osteoprotegerin,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF11 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0300-0664
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14678293-Aging,
pubmed-meshheading:14678293-Arthritis, Rheumatoid,
pubmed-meshheading:14678293-Carrier Proteins,
pubmed-meshheading:14678293-Case-Control Studies,
pubmed-meshheading:14678293-Child,
pubmed-meshheading:14678293-Child, Preschool,
pubmed-meshheading:14678293-Female,
pubmed-meshheading:14678293-Glycoproteins,
pubmed-meshheading:14678293-Homeostasis,
pubmed-meshheading:14678293-Humans,
pubmed-meshheading:14678293-Infant,
pubmed-meshheading:14678293-Male,
pubmed-meshheading:14678293-Membrane Glycoproteins,
pubmed-meshheading:14678293-Osteoprotegerin,
pubmed-meshheading:14678293-Puberty, Precocious,
pubmed-meshheading:14678293-RANK Ligand,
pubmed-meshheading:14678293-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:14678293-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:14678293-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:14678293-Reference Values,
pubmed-meshheading:14678293-Turner Syndrome
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pubmed:year |
2004
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pubmed:articleTitle |
Serum osteoprotegerin and receptor activator of nuclear factors kB (RANKL) concentrations in normal children and in children with pubertal precocity, Turner's syndrome and rheumatoid arthritis.
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pubmed:affiliation |
Department of Paediatrics, University of Brescia, Brescia, Italy. mazzolar@master.cci.unibs.it
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pubmed:publicationType |
Journal Article,
Comparative Study
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