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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-16
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pubmed:abstractText |
Glomerular capillary hypertension, a common denominator in various forms of progressive glomerular disease, results in mechanical distention of the capillary tuft, and subsequent injury of the overlying podocyte layer. The mechanisms by which elevated intraglomerular pressure is translated into a maladaptive podocyte response remain poorly understood. Angiotensin II plays a central role in the pathogenesis of chronic renal injury, largely through its actions on the subtype 1 receptor. Accordingly, we have tested the hypothesis that mechanical strain up-regulates local angiotensin II in podocytes, thereby resulting in a progressive reduction in podocyte number.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14675034-Angiotensin II,
pubmed-meshheading:14675034-Animals,
pubmed-meshheading:14675034-Apoptosis,
pubmed-meshheading:14675034-Capillaries,
pubmed-meshheading:14675034-Cell Line, Transformed,
pubmed-meshheading:14675034-Gene Expression,
pubmed-meshheading:14675034-Hypertension, Renal,
pubmed-meshheading:14675034-Kidney Glomerulus,
pubmed-meshheading:14675034-Mechanotransduction, Cellular,
pubmed-meshheading:14675034-Mice,
pubmed-meshheading:14675034-RNA, Messenger,
pubmed-meshheading:14675034-Rats,
pubmed-meshheading:14675034-Receptor, Angiotensin, Type 1,
pubmed-meshheading:14675034-Receptor, Angiotensin, Type 2,
pubmed-meshheading:14675034-Renal Circulation,
pubmed-meshheading:14675034-Stress, Mechanical,
pubmed-meshheading:14675034-Transforming Growth Factor beta,
pubmed-meshheading:14675034-Up-Regulation,
pubmed-meshheading:14675034-Vasoconstrictor Agents
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pubmed:year |
2004
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pubmed:articleTitle |
Activation of a local tissue angiotensin system in podocytes by mechanical strain.
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pubmed:affiliation |
Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, Washington 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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