|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5658
|
|
pubmed:dateCreated |
2004-1-30
|
|
pubmed:abstractText |
The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modifications and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
30
|
|
pubmed:volume |
303
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
644-9
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:14671313-Acetylation,
pubmed-meshheading:14671313-Animals,
pubmed-meshheading:14671313-Blastocyst,
pubmed-meshheading:14671313-Blastomeres,
pubmed-meshheading:14671313-Chromatin,
pubmed-meshheading:14671313-Chromosomes, Mammalian,
pubmed-meshheading:14671313-Dosage Compensation, Genetic,
pubmed-meshheading:14671313-Embryo, Mammalian,
pubmed-meshheading:14671313-Embryonic and Fetal Development,
pubmed-meshheading:14671313-Epigenesis, Genetic,
pubmed-meshheading:14671313-Female,
pubmed-meshheading:14671313-Genomic Imprinting,
pubmed-meshheading:14671313-Histones,
pubmed-meshheading:14671313-Male,
pubmed-meshheading:14671313-Methylation,
pubmed-meshheading:14671313-Mice,
pubmed-meshheading:14671313-Morula,
pubmed-meshheading:14671313-RNA, Untranslated,
pubmed-meshheading:14671313-Transcription, Genetic,
pubmed-meshheading:14671313-X Chromosome
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Epigenetic dynamics of imprinted X inactivation during early mouse development.
|
|
pubmed:affiliation |
CNRS UMR218, Curie Institute, 26 rue d'Ulm, Paris 75005, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
