|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009208,
umls-concept:C0017262,
umls-concept:C0030940,
umls-concept:C0031727,
umls-concept:C0079633,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0442805,
umls-concept:C1257901,
umls-concept:C1711178,
umls-concept:C1879547,
umls-concept:C2911684
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2003-12-5
|
|
pubmed:abstractText |
We have shown that serine proteases in German cockroach extract increase TNF-alpha-induced expression of IL-8 in human bronchial epithelial cells. The mechanism by which cockroach proteases regulate cytokine expression is unknown; however, protease-activated receptors (PARs) might play a role.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0091-6749
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
112
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1112-8
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:14657869-Allergens,
pubmed-meshheading:14657869-Animals,
pubmed-meshheading:14657869-Bronchi,
pubmed-meshheading:14657869-Cell Line,
pubmed-meshheading:14657869-Cockroaches,
pubmed-meshheading:14657869-Endopeptidases,
pubmed-meshheading:14657869-Epithelial Cells,
pubmed-meshheading:14657869-Humans,
pubmed-meshheading:14657869-Interleukin-8,
pubmed-meshheading:14657869-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14657869-Promoter Regions, Genetic,
pubmed-meshheading:14657869-Receptor, PAR-2,
pubmed-meshheading:14657869-Transcription, Genetic,
pubmed-meshheading:14657869-Tumor Necrosis Factor-alpha,
pubmed-meshheading:14657869-ras Proteins
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR)-2 and extracellular-signal-regulated kinase.
|
|
pubmed:affiliation |
Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
