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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5651
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pubmed:dateCreated |
2003-12-5
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pubmed:abstractText |
We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect. The transient expression of the rutabaga-encoded adenylyl cyclase in the mushroom bodies of the adult brain was necessary and sufficient to rescue the rutabaga memory deficit, which rules out a developmental brain defect in the etiology of this deficit and demonstrates an acute role for rutabaga in memory formation in these neurons. The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GAL4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/GAL80 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
302
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1765-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14657498-Adenylate Cyclase,
pubmed-meshheading:14657498-Animals,
pubmed-meshheading:14657498-Animals, Genetically Modified,
pubmed-meshheading:14657498-Cloning, Molecular,
pubmed-meshheading:14657498-DNA-Binding Proteins,
pubmed-meshheading:14657498-Drosophila,
pubmed-meshheading:14657498-Drosophila Proteins,
pubmed-meshheading:14657498-Gene Expression,
pubmed-meshheading:14657498-Genotype,
pubmed-meshheading:14657498-Green Fluorescent Proteins,
pubmed-meshheading:14657498-Luminescent Proteins,
pubmed-meshheading:14657498-Memory,
pubmed-meshheading:14657498-Mushroom Bodies,
pubmed-meshheading:14657498-Neuronal Plasticity,
pubmed-meshheading:14657498-Phenotype,
pubmed-meshheading:14657498-Repressor Proteins,
pubmed-meshheading:14657498-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:14657498-Temperature,
pubmed-meshheading:14657498-Transcription Factors,
pubmed-meshheading:14657498-Transgenes
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pubmed:year |
2003
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pubmed:articleTitle |
Spatiotemporal rescue of memory dysfunction in Drosophila.
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pubmed:affiliation |
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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