| pubmed-article:14645572 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0035236 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:14645572 | lifeskim:mentions | umls-concept:C0914671 | lld:lifeskim |
| pubmed-article:14645572 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:14645572 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14645572 | pubmed:abstractText | CpG oligodeoxynucleotides (ODN) were identified that stimulated immunoglobulin production and cell proliferation in cotton rat cells in vitro. Three of these ODN were used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory syncytial virus fusion (F) protein. The CpG ODN markedly increased the cotton rat humoral neutralizing-antibody response to respiratory syncytial virus. Such immunized animals had a marked reduction in the production of infectious virus after a live-virus challenge. Animals immunized with the combination of F protein and CpG developed enhanced pulmonary pathology consisting of alveolitis and interstitial pneumonitis after a live-virus challenge. Similar enhanced disease has been seen in cotton rats and children immunized with formalin-inactivated respiratory syncytial virus. | lld:pubmed |
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| pubmed-article:14645572 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14645572 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14645572 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14645572 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14645572 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:14645572 | pubmed:author | pubmed-author:KlinmanDennis... | lld:pubmed |
| pubmed-article:14645572 | pubmed:author | pubmed-author:PrinceGregory... | lld:pubmed |
| pubmed-article:14645572 | pubmed:author | pubmed-author:PorterDavid... | lld:pubmed |
| pubmed-article:14645572 | pubmed:author | pubmed-author:MondJames JJJ | lld:pubmed |
| pubmed-article:14645572 | pubmed:author | pubmed-author:YimKevin CKC | lld:pubmed |
| pubmed-article:14645572 | pubmed:author | pubmed-author:LanSteve JSJ | lld:pubmed |
| pubmed-article:14645572 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14645572 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:14645572 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14645572 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14645572 | pubmed:pagination | 13156-60 | lld:pubmed |
| pubmed-article:14645572 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14645572 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14645572 | pubmed:articleTitle | Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant. | lld:pubmed |
| pubmed-article:14645572 | pubmed:affiliation | Virion Systems, Inc., Rockville, Maryland 20850, USA. gprince@erols.com | lld:pubmed |
| pubmed-article:14645572 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14645572 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14645572 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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