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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
CpG oligodeoxynucleotides (ODN) were identified that stimulated immunoglobulin production and cell proliferation in cotton rat cells in vitro. Three of these ODN were used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory syncytial virus fusion (F) protein. The CpG ODN markedly increased the cotton rat humoral neutralizing-antibody response to respiratory syncytial virus. Such immunized animals had a marked reduction in the production of infectious virus after a live-virus challenge. Animals immunized with the combination of F protein and CpG developed enhanced pulmonary pathology consisting of alveolitis and interstitial pneumonitis after a live-virus challenge. Similar enhanced disease has been seen in cotton rats and children immunized with formalin-inactivated respiratory syncytial virus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-10078603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-10576209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-10627641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-10960663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-11044072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-11207303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-11257389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-11535341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-11642598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-11714962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-11861616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-12085325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-2251875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-362946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-4020957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-4305197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-4305198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-4305199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-4305200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-5933417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-8195619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-8380066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-8627759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-8989345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-9794366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14645572-9841818
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13156-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14645572-Adjuvants, Immunologic,
pubmed-meshheading:14645572-Administration, Intranasal,
pubmed-meshheading:14645572-Animals,
pubmed-meshheading:14645572-Antibodies, Viral,
pubmed-meshheading:14645572-CpG Islands,
pubmed-meshheading:14645572-Disease Models, Animal,
pubmed-meshheading:14645572-Female,
pubmed-meshheading:14645572-Humans,
pubmed-meshheading:14645572-Immunization,
pubmed-meshheading:14645572-Lung,
pubmed-meshheading:14645572-Male,
pubmed-meshheading:14645572-Mucous Membrane,
pubmed-meshheading:14645572-Oligodeoxyribonucleotides,
pubmed-meshheading:14645572-Respiratory Syncytial Virus Infections,
pubmed-meshheading:14645572-Respiratory Syncytial Virus Vaccines,
pubmed-meshheading:14645572-Respiratory Syncytial Viruses,
pubmed-meshheading:14645572-Sigmodontinae,
pubmed-meshheading:14645572-Viral Fusion Proteins,
pubmed-meshheading:14645572-Viral Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant.
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pubmed:affiliation |
Virion Systems, Inc., Rockville, Maryland 20850, USA. gprince@erols.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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