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rdf:type |
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lifeskim:mentions |
umls-concept:C0007578,
umls-concept:C0033684,
umls-concept:C0035611,
umls-concept:C0043481,
umls-concept:C0085262,
umls-concept:C0205314,
umls-concept:C0205341,
umls-concept:C0332256,
umls-concept:C0679622,
umls-concept:C0851285,
umls-concept:C1260969,
umls-concept:C1428449,
umls-concept:C1707391
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pubmed:issue |
6
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pubmed:dateCreated |
2003-11-24
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pubmed:abstractText |
Cell adhesion molecules play a critical role in cell contacts, whether cell-cell or cell-matrix, and are regulated by multiple signaling pathways. In this report, we identify a novel ring zinc finger-leucine-rich repeat containing protein (RIFLE) and show that RIFLE, expressed in PC12 cells, enhances the Serine (Ser)21/9 phosphorylation of glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) resulting in the inhibition of GSK-3 kinase activity and increase of beta-catenin levels. RIFLE expression also is associated with elevated E-cadherin protein levels but not N-cadherin. The regulation of these cell adhesion-associated molecules by RIFLE is accompanied by a significant increase in cell-cell and cell-matrix adhesion. Moreover, increase in cell-cell adhesion but not cell-matrix adhesion by RIFLE can be mimicked by selective inhibition of GSK-3. Our results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type IV,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 alpha,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta,
http://linkedlifedata.com/resource/pubmed/chemical/leucine-rich repeat proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0730-2312
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1224-41
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:14635195-Amino Acid Sequence,
pubmed-meshheading:14635195-Animals,
pubmed-meshheading:14635195-Base Sequence,
pubmed-meshheading:14635195-Cadherins,
pubmed-meshheading:14635195-Calcium,
pubmed-meshheading:14635195-Cell Adhesion Molecules,
pubmed-meshheading:14635195-Collagen Type IV,
pubmed-meshheading:14635195-Cytoskeletal Proteins,
pubmed-meshheading:14635195-Fibronectins,
pubmed-meshheading:14635195-Glycogen Synthase Kinase 3,
pubmed-meshheading:14635195-Humans,
pubmed-meshheading:14635195-Molecular Sequence Data,
pubmed-meshheading:14635195-PC12 Cells,
pubmed-meshheading:14635195-Phosphorylation,
pubmed-meshheading:14635195-Proteins,
pubmed-meshheading:14635195-Proto-Oncogene Proteins,
pubmed-meshheading:14635195-Rats,
pubmed-meshheading:14635195-Sequence Alignment,
pubmed-meshheading:14635195-Signal Transduction,
pubmed-meshheading:14635195-Tissue Distribution,
pubmed-meshheading:14635195-Trans-Activators,
pubmed-meshheading:14635195-Wnt Proteins,
pubmed-meshheading:14635195-Zinc Fingers,
pubmed-meshheading:14635195-beta Catenin
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pubmed:year |
2003
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pubmed:articleTitle |
RIFLE: a novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells.
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pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
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pubmed:publicationType |
Journal Article
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