| pubmed-article:14634061 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C1366876 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C1833235 | lld:lifeskim |
| pubmed-article:14634061 | lifeskim:mentions | umls-concept:C1819459 | lld:lifeskim |
| pubmed-article:14634061 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14634061 | pubmed:dateCreated | 2004-3-5 | lld:pubmed |
| pubmed-article:14634061 | pubmed:abstractText | Acute ethanol consumption has been linked to an increase in infectious complications in trauma and burn patients. Ethanol modifies production of a variety of macrophage-derived immunoregulatory mediators. Lipopolysaccharide (LPS), a potent stimulator of inflammatory responses in macrophages, activates several intracellular signaling pathways, including mitogen-activated protein kinases (MAPK). In the current study, we investigated the effect of acute ethanol exposure on in vivo activation of p38 and extracellularly regulated kinases 1 and 2 (ERK1/2) MAPK in murine macrophages and the corresponding, LPS-stimulated interleukin (IL)-6 production. We demonstrated that a single dose of ethanol transiently down-regulated p38 and ERK1/2 activation levels (3-24 h after treatment) and impaired IL-6 synthesis. Ethanol-related reduction in IL-6 production was not further affected by the presence of inhibitors of p38 and ERK1/2 (SB 202190 and PD 98059, respectively). These results demonstrate that acute ethanol exposure can impair macrophage IL-6 production and indicate that this effect may result from ethanol-induced alterations in intracellular signaling through p38 and ERK1/2. | lld:pubmed |
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| pubmed-article:14634061 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14634061 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14634061 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14634061 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14634061 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14634061 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:14634061 | pubmed:author | pubmed-author:KovacsElizabe... | lld:pubmed |
| pubmed-article:14634061 | pubmed:author | pubmed-author:ChoudhryMashk... | lld:pubmed |
| pubmed-article:14634061 | pubmed:author | pubmed-author:GoralJoannaJ | lld:pubmed |
| pubmed-article:14634061 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14634061 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:14634061 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14634061 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14634061 | pubmed:pagination | 553-9 | lld:pubmed |
| pubmed-article:14634061 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14634061 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14634061 | pubmed:articleTitle | Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. | lld:pubmed |
| pubmed-article:14634061 | pubmed:affiliation | Department of Cell Biology, Loyola University Medical Center, Maywood, IL 60153, USA. | lld:pubmed |
| pubmed-article:14634061 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14634061 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14634061 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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