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rdf:type |
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lifeskim:mentions |
umls-concept:C0001962,
umls-concept:C0024432,
umls-concept:C0035820,
umls-concept:C0205178,
umls-concept:C0332157,
umls-concept:C0752312,
umls-concept:C1366765,
umls-concept:C1366876,
umls-concept:C1370600,
umls-concept:C1819459,
umls-concept:C1833235
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-5
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pubmed:abstractText |
Acute ethanol consumption has been linked to an increase in infectious complications in trauma and burn patients. Ethanol modifies production of a variety of macrophage-derived immunoregulatory mediators. Lipopolysaccharide (LPS), a potent stimulator of inflammatory responses in macrophages, activates several intracellular signaling pathways, including mitogen-activated protein kinases (MAPK). In the current study, we investigated the effect of acute ethanol exposure on in vivo activation of p38 and extracellularly regulated kinases 1 and 2 (ERK1/2) MAPK in murine macrophages and the corresponding, LPS-stimulated interleukin (IL)-6 production. We demonstrated that a single dose of ethanol transiently down-regulated p38 and ERK1/2 activation levels (3-24 h after treatment) and impaired IL-6 synthesis. Ethanol-related reduction in IL-6 production was not further affected by the presence of inhibitors of p38 and ERK1/2 (SB 202190 and PD 98059, respectively). These results demonstrate that acute ethanol exposure can impair macrophage IL-6 production and indicate that this effect may result from ethanol-induced alterations in intracellular signaling through p38 and ERK1/2.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0741-5400
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
553-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14634061-Adjuvants, Immunologic,
pubmed-meshheading:14634061-Animals,
pubmed-meshheading:14634061-Down-Regulation,
pubmed-meshheading:14634061-Ethanol,
pubmed-meshheading:14634061-Interleukin-6,
pubmed-meshheading:14634061-Lipopolysaccharides,
pubmed-meshheading:14634061-Macrophages,
pubmed-meshheading:14634061-Male,
pubmed-meshheading:14634061-Mice,
pubmed-meshheading:14634061-Mice, Inbred C57BL,
pubmed-meshheading:14634061-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:14634061-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:14634061-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14634061-Signal Transduction,
pubmed-meshheading:14634061-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2004
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pubmed:articleTitle |
Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK.
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pubmed:affiliation |
Department of Cell Biology, Loyola University Medical Center, Maywood, IL 60153, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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