Source:http://linkedlifedata.com/resource/pubmed/id/14614750
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2003-11-17
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pubmed:abstractText |
Hypoxia and ischemia play important roles in the onset and progression of glaucoma. Insulin-like growth factors (IGF) are important neurotrophic agents that respond to hypoxia-ischemia. In this study, we enrolled 60 primary open angle glaucoma (POAG) patients and 104 healthy volunteers from the China Medical College Hospital. Among the polymorphism of IGFs gene, exon 9 Apa I C/T gene polymorphism is the most frequently seen. The polymorphism was observed following polymerase chain reaction based restriction analysis used to to resolve the relationship between IGF-II exon 9 Apa I C/T gene polymorphism and POAG. The distribution of the IGF-II exon 9 gene polymorphism showed statistical differences in the distribution of genotype frequencies between POAG patients and normal controls (P=0.010). The odds ratio of C/C homozygote was 0.266 (95% confidence interval=0.636 approximately 0.111). IGF-II is an important neurotrophic agent and regulates the suffering of POAG. C/C homozygote of IGF-II exon 9 Apa I C/T gene polymorphism is a useful marker of POAG in Chinese.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0887-8013
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14614750-Adult,
pubmed-meshheading:14614750-Aged,
pubmed-meshheading:14614750-Asian Continental Ancestry Group,
pubmed-meshheading:14614750-DNA,
pubmed-meshheading:14614750-Female,
pubmed-meshheading:14614750-Genetic Predisposition to Disease,
pubmed-meshheading:14614750-Glaucoma, Open-Angle,
pubmed-meshheading:14614750-Hospitals, University,
pubmed-meshheading:14614750-Humans,
pubmed-meshheading:14614750-Insulin-Like Growth Factor II,
pubmed-meshheading:14614750-Male,
pubmed-meshheading:14614750-Middle Aged,
pubmed-meshheading:14614750-Polymerase Chain Reaction,
pubmed-meshheading:14614750-Polymorphism, Genetic
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pubmed:year |
2003
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pubmed:articleTitle |
Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma.
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pubmed:affiliation |
Department of Medical Genetics and Pediatrics, China Medical University Hospital, Taichung, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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