| pubmed-article:14614133 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C0118036 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C0900627 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C1333226 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C1705335 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:14614133 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:14614133 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:14614133 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14614133 | pubmed:abstractText | Fragile X syndrome (FXS) is a common inherited cause of mental retardation resulting from the absence of the fragile X mental retardation protein (FMRP). FMRP is thought to regulate the translation of target mRNAs, including its own transcript. Here we show that the levels of FMRP are rapidly up-regulated in primary cortical neurons in response to the type-I metabotropic glutamate receptor (mGluR) agonist S-3,5-dihydrophenylglycine. These changes require new protein synthesis but not transcription and are specific to mGluR activation. We also demonstrate that the mRNA for PSD-95, a scaffolding protein involved in synaptic plasticity, contains a highly conserved canonical binding site for FMRP within its 3' UTR. Furthermore, PSD-95 is rapidly translated in response to S-3,5-dihydrophenylglycine. Finally, we show that these mGluR-dependent changes in PSD-95 expression are lost in neurons derived from FMRP knockout mice, a model of FXS. Taken together, these studies suggest that FMRP is required for mGluR-dependent translation of PSD-95 and provide insights into the pathophysiology of FXS. | lld:pubmed |
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| pubmed-article:14614133 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14614133 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14614133 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14614133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14614133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14614133 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14614133 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:14614133 | pubmed:author | pubmed-author:MalterJames... | lld:pubmed |
| pubmed-article:14614133 | pubmed:author | pubmed-author:ToddPeter KPK | lld:pubmed |
| pubmed-article:14614133 | pubmed:author | pubmed-author:MackKenneth... | lld:pubmed |
| pubmed-article:14614133 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14614133 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:14614133 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:14614133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14614133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14614133 | pubmed:pagination | 14374-8 | lld:pubmed |
| pubmed-article:14614133 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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