Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2003-12-3
pubmed:abstractText
Fragile X syndrome (FXS) is a common inherited cause of mental retardation resulting from the absence of the fragile X mental retardation protein (FMRP). FMRP is thought to regulate the translation of target mRNAs, including its own transcript. Here we show that the levels of FMRP are rapidly up-regulated in primary cortical neurons in response to the type-I metabotropic glutamate receptor (mGluR) agonist S-3,5-dihydrophenylglycine. These changes require new protein synthesis but not transcription and are specific to mGluR activation. We also demonstrate that the mRNA for PSD-95, a scaffolding protein involved in synaptic plasticity, contains a highly conserved canonical binding site for FMRP within its 3' UTR. Furthermore, PSD-95 is rapidly translated in response to S-3,5-dihydrophenylglycine. Finally, we show that these mGluR-dependent changes in PSD-95 expression are lost in neurons derived from FMRP knockout mice, a model of FXS. Taken together, these studies suggest that FMRP is required for mGluR-dependent translation of PSD-95 and provide insights into the pathophysiology of FXS.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10197530, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10461219, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10516309, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10567518, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10629226, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10648701, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10748194, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10767313, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10818003, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-10825658, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11046149, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11082065, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11157796, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11223852, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11376146, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11387401, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11416194, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11431509, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11487634, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11532944, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11606784, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11640920, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11687813, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11719188, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11719189, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11733059, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11953750, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-11955437, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-12032354, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-12591163, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-8102206, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-8358432, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-8522953, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-8826475, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9030614, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9144248, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9144249, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9285783, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9326332, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9454832, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9624140, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9659908, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9705485, http://linkedlifedata.com/resource/pubmed/commentcorrection/14614133-9853749
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3,5-dihydroxyphenylglycine, http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Fmr1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Fmr1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Fragile X Mental Retardation Protein, http://linkedlifedata.com/resource/pubmed/chemical/Glycine, http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Kinase, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate, http://linkedlifedata.com/resource/pubmed/chemical/Resorcinols, http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor..., http://linkedlifedata.com/resource/pubmed/chemical/postsynaptic density proteins
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14374-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
More...