pubmed-article:14602796 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:14602796 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
pubmed-article:14602796 | lifeskim:mentions | umls-concept:C0385463 | lld:lifeskim |
pubmed-article:14602796 | lifeskim:mentions | umls-concept:C0027726 | lld:lifeskim |
pubmed-article:14602796 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
pubmed-article:14602796 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
pubmed-article:14602796 | pubmed:issue | 11 | lld:pubmed |
pubmed-article:14602796 | pubmed:dateCreated | 2003-11-6 | lld:pubmed |
pubmed-article:14602796 | pubmed:abstractText | In patients with nephrotic syndrome, severe proteinuria is related to significant leptinuria; serum leptin levels remain unchanged. The goal of this study was to elucidate the role of the soluble leptin receptor (sOB-R) in maintaining serum leptin levels in nephrotic patients. Patients with proteinuria were compared with patients in remission of nephrotic syndrome. In this group proteinuria did not exceed 100 mg/m(2) of body surface area per day. The period of remission was at least 6 months and was equal in all patients included. The sOB-R level (mean +/- SD) in serum of patients with nephrotic syndrome was significantly higher during proteinuria (61.0 +/- 17.8 ng/ml) than those in remission or in control patients (36.7 +/- 7.0 ng/ml, 36.6 +/- 12.0 ng/ml, respectively, P < 0.0001). The ratio between serum leptin levels and the sOB-R (free leptin index) was significantly lower in the proteinuric group (0.012 +/- 0.005 vs. 0.06 +/- 0.03 and 0.07 +/- 0.03 in remission and control group, respectively) (P < 0.001). Urinary sOB-R excretion was similar in all groups. Our data suggest that the counteracting pathway in case of leptin loss in parallel to severe proteinuria in nephrotic syndrome is the up-regulation of its soluble binding protein in serum, which can keep total serum leptin levels constant. | lld:pubmed |
pubmed-article:14602796 | pubmed:language | eng | lld:pubmed |
pubmed-article:14602796 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14602796 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:14602796 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14602796 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14602796 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14602796 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14602796 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:14602796 | pubmed:month | Nov | lld:pubmed |
pubmed-article:14602796 | pubmed:issn | 0021-972X | lld:pubmed |
pubmed-article:14602796 | pubmed:author | pubmed-author:DötschJörgJ | lld:pubmed |
pubmed-article:14602796 | pubmed:author | pubmed-author:RascherWolfga... | lld:pubmed |
pubmed-article:14602796 | pubmed:author | pubmed-author:GröschlMichae... | lld:pubmed |
pubmed-article:14602796 | pubmed:author | pubmed-author:RauhManfredM | lld:pubmed |
pubmed-article:14602796 | pubmed:author | pubmed-author:KratzschJürge... | lld:pubmed |
pubmed-article:14602796 | pubmed:author | pubmed-author:SchrothMichae... | lld:pubmed |
pubmed-article:14602796 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:14602796 | pubmed:volume | 88 | lld:pubmed |
pubmed-article:14602796 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:14602796 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:14602796 | pubmed:pagination | 5497-501 | lld:pubmed |
pubmed-article:14602796 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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pubmed-article:14602796 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:14602796 | pubmed:articleTitle | Increased soluble leptin receptor in children with nephrotic syndrome. | lld:pubmed |
pubmed-article:14602796 | pubmed:affiliation | Klinik mit Poliklinik für Kinder und Jugendliche, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany. michael_scroth@yahoo.de | lld:pubmed |
pubmed-article:14602796 | pubmed:publicationType | Journal Article | lld:pubmed |
entrez-gene:3953 | entrezgene:pubmed | pubmed-article:14602796 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14602796 | lld:entrezgene |