Source:http://linkedlifedata.com/resource/pubmed/id/14602796
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2003-11-6
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| pubmed:abstractText |
In patients with nephrotic syndrome, severe proteinuria is related to significant leptinuria; serum leptin levels remain unchanged. The goal of this study was to elucidate the role of the soluble leptin receptor (sOB-R) in maintaining serum leptin levels in nephrotic patients. Patients with proteinuria were compared with patients in remission of nephrotic syndrome. In this group proteinuria did not exceed 100 mg/m(2) of body surface area per day. The period of remission was at least 6 months and was equal in all patients included. The sOB-R level (mean +/- SD) in serum of patients with nephrotic syndrome was significantly higher during proteinuria (61.0 +/- 17.8 ng/ml) than those in remission or in control patients (36.7 +/- 7.0 ng/ml, 36.6 +/- 12.0 ng/ml, respectively, P < 0.0001). The ratio between serum leptin levels and the sOB-R (free leptin index) was significantly lower in the proteinuric group (0.012 +/- 0.005 vs. 0.06 +/- 0.03 and 0.07 +/- 0.03 in remission and control group, respectively) (P < 0.001). Urinary sOB-R excretion was similar in all groups. Our data suggest that the counteracting pathway in case of leptin loss in parallel to severe proteinuria in nephrotic syndrome is the up-regulation of its soluble binding protein in serum, which can keep total serum leptin levels constant.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
88
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
5497-501
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14602796-Adolescent,
pubmed-meshheading:14602796-Child,
pubmed-meshheading:14602796-Female,
pubmed-meshheading:14602796-Humans,
pubmed-meshheading:14602796-Leptin,
pubmed-meshheading:14602796-Male,
pubmed-meshheading:14602796-Nephrotic Syndrome,
pubmed-meshheading:14602796-Proteinuria,
pubmed-meshheading:14602796-Receptors, Cell Surface,
pubmed-meshheading:14602796-Receptors, Leptin,
pubmed-meshheading:14602796-Solubility,
pubmed-meshheading:14602796-Up-Regulation
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| pubmed:year |
2003
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| pubmed:articleTitle |
Increased soluble leptin receptor in children with nephrotic syndrome.
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| pubmed:affiliation |
Klinik mit Poliklinik für Kinder und Jugendliche, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany. michael_scroth@yahoo.de
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| pubmed:publicationType |
Journal Article
|