|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003864,
umls-concept:C0013227,
umls-concept:C0205177,
umls-concept:C0205531,
umls-concept:C0220781,
umls-concept:C0226896,
umls-concept:C0243077,
umls-concept:C0442027,
umls-concept:C0812246,
umls-concept:C1456820,
umls-concept:C1527415,
umls-concept:C1707689,
umls-concept:C1883254
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|
pubmed:issue |
22
|
|
pubmed:dateCreated |
2003-10-31
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|
pubmed:abstractText |
A novel series of TNF inhibitors was identified based on the screening of existing MMP inhibitor libraries. Further SAR optimization led to the discovery of a novel lead compound. Its synthesis, efficacy in experimental animal models, and pharmacokinetic data are discussed.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:ArzenoHumbertoH,
pubmed-author:ChenJian JeffreyJJ,
pubmed-author:ChuFrancesF,
pubmed-author:DewdneyNolanN,
pubmed-author:EuguiElsieE,
pubmed-author:HuangJaneJ,
pubmed-author:KimYongY,
pubmed-author:LinXiaohongX,
pubmed-author:MartinRobert LRL,
pubmed-author:MirkovichAnnaA,
pubmed-author:SarmaKeshabK,
pubmed-author:Van WartHarold EHE,
pubmed-author:WalkerKeith A MKA
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|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3951-4
|
|
pubmed:dateRevised |
2004-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:14592482-Animals,
pubmed-meshheading:14592482-Antirheumatic Agents,
pubmed-meshheading:14592482-Arthritis, Rheumatoid,
pubmed-meshheading:14592482-Disease Models, Animal,
pubmed-meshheading:14592482-Drug Design,
pubmed-meshheading:14592482-Humans,
pubmed-meshheading:14592482-Mice,
pubmed-meshheading:14592482-Structure-Activity Relationship,
pubmed-meshheading:14592482-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2003
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|
pubmed:articleTitle |
Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs.
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|
pubmed:affiliation |
Roche Bioscience, 3401 Hillview Avenue, Palo Alto, CA 94304, USA. jianc@amgen.com
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pubmed:publicationType |
Journal Article
|
