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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1993-1-13
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pubmed:abstractText |
Chromogranin A (CGA) has been localized to the large dense cored vesicles (LDV) of sympathetic neurons. SDS-PAGE and immunoblotting of soluble LDV proteins from ox and dog adrenergic neuronal cell bodies, axons and nerve terminals, revealed an increasing number of CGA-immunoreactive forms, consistent with proteolytic processing during axonal transport. Splenic nerve electrical stimulation (10 Hz, 2 min) revealed that, apart from CGA, these CGA-processing products are released from the sheep spleen. The secretion of CGA-derived fragments from sympathetic neurons might suggest a role in the regulation of synaptic transmission.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
314
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1459242-Adrenergic Fibers,
pubmed-meshheading:1459242-Animals,
pubmed-meshheading:1459242-Biological Transport,
pubmed-meshheading:1459242-Blotting, Western,
pubmed-meshheading:1459242-Cattle,
pubmed-meshheading:1459242-Chromogranin A,
pubmed-meshheading:1459242-Chromogranins,
pubmed-meshheading:1459242-Dogs,
pubmed-meshheading:1459242-Protein Processing, Post-Translational,
pubmed-meshheading:1459242-Sheep,
pubmed-meshheading:1459242-Spleen,
pubmed-meshheading:1459242-Subcellular Fractions
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pubmed:year |
1992
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pubmed:articleTitle |
Chromogranin A processing in sympathetic neurons and release of chromogranin A fragments from sheep spleen.
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pubmed:affiliation |
Department of Medicine, University of Antwerp (UIA), Wilrijk, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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