Chromogranin A

Source:http://linkedlifedata.com/resource/umls/id/C0055633

MSH: A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.,NCI: A neuroendocrine product of certain prostate cells. Adds to the predictive value of prostate specific antigen in the evaluation of men with prostate disease. (from Medscape),NCI: Chromogranin A (CHGA, Secretory Protein I, Parathyroid Secretory Protein, PSP) is stored and released with catecholamines in the adrenal medulla, as well as with PTH from the parathyroid gland. CHGA is also secreted by many endocrine neoplasms: pheochromocytoma, parathyroid adenoma, medullary thyroid carcinoma, carcinoids, oat-cell lung cancer, pancreatic islet-cell tumors, and aortic-body tumor. Its secretion is inversely pr

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