Linked Life Data

14584757

Source:http://linkedlifedata.com/resource/pubmed/id/14584757

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-10-30
pubmed:abstractText
Recent studies have shown that a single nucleotide polymorphism of A/G substitution in the androgen response element-1 (ARE-1) of the promoter for the prostate-specific antigen gene is a biomarker of prostate cancer. Portugese men with prostate cancer have a high percentage (43%) of the AA polymorphism of the gene (41% AG, 16% GG), whereas healthy Japanese men have a much lower rate (5%) of the AA polymorphism, (31% AG, 64% GG). The goal of the present study was to see whether or not the Chinese also have a low rate of the AA polymorphism. This study used 94 specimens of cord blood that were the leftover waste of cord blood banking. The samples were collected from Chinese infants onto filter paper, dried, and shipped to Rochester, MN, USA, for PCR amplification and analysis. The observed rate of the AA polymorphism in the samples was very low (5%), with 26% AG, 69% GG. The low incidence of AA polymorphism appears to be a trait of Asians that may reduce their risk of prostate cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0091-7370
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
429-34
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Polymorphisms of prostate-specific antigen gene promoter: determination from cord blood collected on filter paper.
pubmed:affiliation
Guangdong Hematopoietic Stem Cell Therapy Technology Center, Guangzhou, China.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.