Linked Life Data

14578618

Source:http://linkedlifedata.com/resource/pubmed/id/14578618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2003-10-27
pubmed:abstractText
In rat models of transplant vasculopathy, the strongest staining of CXCR3 is observed in the innermost layer of the neointima and because neointimal hyperplasia is seen after coronary angioplasty, the CXC chemokines may be targets for preventing stenosis. The expression of leukocyte surface chemokine receptors (CCR2/CCR5/CXCR2/CXCR3), as determined by flow cytometry, and plasma concentrations of monocyte chemoattractant protein (MCP)-1 and interferon-inducible protein (IP)10, as determined by enzyme immunoassays, were investigated in 55 patients with coronary artery disease (CAD) who underwent percutaneous transluminal coronary angioplasty (PTCA) and 20 patients without significant coronary stenosis based on the results of coronary catheterization during the same period (C group). The patients with CAD were divided into 3 groups: 20 with de novo stenosis (D group), 15 with restenosis (R group) and 20 without restenosis (N group) after PTCA. CXCR3 expression on lymphocytes, but not monocytes, in the R group was significantly lower than that in the C group. Although the plasma concentrations of IP10 in the D and N groups did not differ from that in the C group, the concentration in the R group was significantly higher. Increased plasma concentrations of IP10 were accompanied by a compensatory decrease in the CXCR3 expression on lymphocytes, but not monocytes, suggesting that a high plasma concentration of IP10 strongly induces monocytes signaling. The CXCR3 - plasma IP10 chemokine receptor - chemokine interaction on monocytes may affect the development of coronary restenosis, but not de novo stenosis, in patients with CAD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1346-9843
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
851-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14578618-Aged, pubmed-meshheading:14578618-Case-Control Studies, pubmed-meshheading:14578618-Chemokine CXCL10, pubmed-meshheading:14578618-Chemokines, CXC, pubmed-meshheading:14578618-Coronary Artery Disease, pubmed-meshheading:14578618-Coronary Restenosis, pubmed-meshheading:14578618-Coronary Stenosis, pubmed-meshheading:14578618-Female, pubmed-meshheading:14578618-Flow Cytometry, pubmed-meshheading:14578618-Humans, pubmed-meshheading:14578618-Lymphocytes, pubmed-meshheading:14578618-Male, pubmed-meshheading:14578618-Middle Aged, pubmed-meshheading:14578618-Monocytes, pubmed-meshheading:14578618-Protein Binding, pubmed-meshheading:14578618-Receptors, CXCR3, pubmed-meshheading:14578618-Receptors, Chemokine, pubmed-meshheading:14578618-Sex Factors, pubmed-meshheading:14578618-Signal Transduction
pubmed:year
2003
pubmed:articleTitle
CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary artery disease.
pubmed:affiliation
Department of Cardiology, Fukuoka University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't