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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2003-10-22
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pubmed:abstractText |
The mitogen-activated protein kinase (MAPK) group of serine/threonine protein kinases mediates the response of cells to many extracellular stimuli such as cytokines and growth factors. These protein kinases include the extracellular signal-regulated protein kinases (ERK) and two stress-activated protein kinases (SAPK), the c-Jun N-terminal kinases (JNK), and the p38 MAPK. The enzymes are evolutionarily conserved and are activated by a common mechanism that involves a protein kinase cascade. Scaffold proteins have been proposed to interact with MAPK pathway components to create a functional signaling module and to control the specificity of signal transduction. Here we critically evaluate the evidence that supports a physiologically relevant role of MAPK scaffold proteins in mammals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Arrestins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Contractile Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DUSP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dual-Specificity Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/KSR-1 protein kinase,
http://linkedlifedata.com/resource/pubmed/chemical/LAMTOR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP3K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAPK8IP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Map3k1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mapk8ip protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoprotein Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/beta-arrestin,
http://linkedlifedata.com/resource/pubmed/chemical/filamins
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pubmed:status |
MEDLINE
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pubmed:issn |
1081-0706
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-118
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:14570565-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:14570565-Animals,
pubmed-meshheading:14570565-Arrestins,
pubmed-meshheading:14570565-Carrier Proteins,
pubmed-meshheading:14570565-Contractile Proteins,
pubmed-meshheading:14570565-Dual-Specificity Phosphatases,
pubmed-meshheading:14570565-Humans,
pubmed-meshheading:14570565-MAP Kinase Kinase Kinase 1,
pubmed-meshheading:14570565-MAP Kinase Kinase Kinases,
pubmed-meshheading:14570565-MAP Kinase Signaling System,
pubmed-meshheading:14570565-Mammals,
pubmed-meshheading:14570565-Microfilament Proteins,
pubmed-meshheading:14570565-Phosphoprotein Phosphatases,
pubmed-meshheading:14570565-Protein Kinases,
pubmed-meshheading:14570565-Protein Tyrosine Phosphatases
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pubmed:year |
2003
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pubmed:articleTitle |
Regulation of MAP kinase signaling modules by scaffold proteins in mammals.
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pubmed:affiliation |
Regulation of Cell Growth Laboratory, NCI-Frederick, P.O. Box B, Frederick, Maryland 21702, USA. dmorrison@ncifcrf.gov
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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