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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2003-10-16
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pubmed:abstractText |
The circadian clock of Drosophila is able to drive behavioral rhythms for many weeks in continuous darkness (DD). The endogenous rhythm generator is thought to be generated by interlocked molecular feedback loops involving circadian transcriptional and posttranscriptional regulation of several clock genes, including period. However, all attempts to demonstrate sustained rhythms of clock gene expression in DD have failed, making it difficult to link the molecular clock models with the circadian behavioral rhythms. Here we restricted expression of a novel period-luciferase transgene to certain clock neurons in the Drosophila brain, permitting us to monitor reporter gene activity in these cells in real-time.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cryptochromes,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Flavoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PER protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Period Circadian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/cryptochrome protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1758-67
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14561400-Animals,
pubmed-meshheading:14561400-Biological Clocks,
pubmed-meshheading:14561400-Brain,
pubmed-meshheading:14561400-Chromosome Mapping,
pubmed-meshheading:14561400-Circadian Rhythm,
pubmed-meshheading:14561400-Cryptochromes,
pubmed-meshheading:14561400-Darkness,
pubmed-meshheading:14561400-Drosophila,
pubmed-meshheading:14561400-Drosophila Proteins,
pubmed-meshheading:14561400-Eye Proteins,
pubmed-meshheading:14561400-Flavoproteins,
pubmed-meshheading:14561400-Gene Expression Profiling,
pubmed-meshheading:14561400-Immunohistochemistry,
pubmed-meshheading:14561400-Luciferases,
pubmed-meshheading:14561400-Luminescent Measurements,
pubmed-meshheading:14561400-Motor Activity,
pubmed-meshheading:14561400-Neurons,
pubmed-meshheading:14561400-Nuclear Proteins,
pubmed-meshheading:14561400-Period Circadian Proteins,
pubmed-meshheading:14561400-Photoperiod,
pubmed-meshheading:14561400-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:14561400-Receptors, G-Protein-Coupled,
pubmed-meshheading:14561400-Transgenes
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pubmed:year |
2003
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pubmed:articleTitle |
A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain.
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pubmed:affiliation |
Universität Regensburg, Institut für Zoologie, Lehrstuhl für Entwicklungsbiologie, 93040, Regensburg, Germany. ralf.stanewsky@biology.uni-regensburg.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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