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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2003-10-13
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pubmed:abstractText |
Several 7-alkoxy-4-anilino-3-quinolinecarbonitriles were synthesized and evaluated for Src kinase inhibitory activity. Optimal inhibition of both Src enzymatic and cellular activity was seen with analogues having a 2,4-dichloro-5-methoxyaniline group at C-4. Compound 18, which has a 1-methylpiperidinemethoxy group at C-7, showed in vivo activity in a xenograft model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3797-800
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14552782-Animals,
pubmed-meshheading:14552782-Cell Line,
pubmed-meshheading:14552782-Cell Transplantation,
pubmed-meshheading:14552782-Enzyme Inhibitors,
pubmed-meshheading:14552782-Fibroblasts,
pubmed-meshheading:14552782-Indicators and Reagents,
pubmed-meshheading:14552782-Magnetic Resonance Spectroscopy,
pubmed-meshheading:14552782-Mass Spectrometry,
pubmed-meshheading:14552782-Mice,
pubmed-meshheading:14552782-Mice, Nude,
pubmed-meshheading:14552782-Nitriles,
pubmed-meshheading:14552782-Quinolines,
pubmed-meshheading:14552782-Rats,
pubmed-meshheading:14552782-Structure-Activity Relationship,
pubmed-meshheading:14552782-Transplantation, Heterologous,
pubmed-meshheading:14552782-src-Family Kinases
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pubmed:year |
2003
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pubmed:articleTitle |
Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity.
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pubmed:affiliation |
Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. bosched@wyeth.com
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pubmed:publicationType |
Journal Article
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