Linked Life Data

1450588

Source:http://linkedlifedata.com/resource/pubmed/id/1450588

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-1-6
pubmed:abstractText
A large number of studies have indicated that carotenoid pigments act as anticarcinogenic agents in animals treated with either ultraviolet light, ultraviolet light with chemicals, or with chemical carcinogens alone. Although pharmacological doses of cartenoids were used in the early experiments, more recent evidence indicates that relatively small doses can be effective. These studies have been complemented by investigations in bacteria and mammalian tissue, either in cell culture or in organ culture, where it has been demonstrated that various carotenoid pigments can prevent mutagenesis, genotoxic effects, or malignant transformation. It would appear that these effects are intrinsic to the carotenoid molecule, and not necessarily due to the metabolic conversion to retinoids. Partially based on these observations, it has been suggested that carotenoid pigments may function as chemopreventive agents for reducing the risk of cancer in humans. Numerous studies are underway to test this hypothesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1023-294X
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-34
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Anticarcinogenic activities of carotenoids in animals and cellular systems.
pubmed:affiliation
Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111-1837.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review