Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1965-12-1
pubmed:abstractText
1. On subcellular fractionation of rabbit kidney by differential and density-gradient centrifugation, a high proportion of the tissue activator of plasminogen activity was found to be particulate and displayed sedimentation properties associated with the lysosome-rich fraction as judged biochemically by the acid-phosphatase activity. 2. The activator activity is closely associated with a latent protease whose activity is enhanced in the presence of Triton X-100 or sodium deoxycholate in the neutral pH range. Besides hydrolysing casein this protease is also capable of attacking fibrinogen at pH7.4. 3. The pH optimum for activator activity and its inhibition by in-hexanoic acid (in-aminocaproic acid) point to its possible similarity to urokinase, an activator of plasminogen present in the urine of most mammals.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13117872, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13249955, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13407698, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13436427, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13460197, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13654273, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13722984, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13808740, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13814337, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-13999781, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-14191573, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-14363113, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-14399609, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-14413370, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-14483249, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-16695652, http://linkedlifedata.com/resource/pubmed/commentcorrection/14343153-16695803
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/ACID PHOSPHATASE, http://linkedlifedata.com/resource/pubmed/keyword/AMINOCAPROIC ACID, http://linkedlifedata.com/resource/pubmed/keyword/CASEIN, http://linkedlifedata.com/resource/pubmed/keyword/CATHEPSIN, http://linkedlifedata.com/resource/pubmed/keyword/CHEMISTRY, ANALYTICAL, http://linkedlifedata.com/resource/pubmed/keyword/EXPERIMENTAL LAB STUDY, http://linkedlifedata.com/resource/pubmed/keyword/GLUCOSEPHOSPHATASE, http://linkedlifedata.com/resource/pubmed/keyword/HEAT, http://linkedlifedata.com/resource/pubmed/keyword/HYDROGEN-ION CONCENTRATION, http://linkedlifedata.com/resource/pubmed/keyword/KIDNEY, http://linkedlifedata.com/resource/pubmed/keyword/LYSOSOMES, http://linkedlifedata.com/resource/pubmed/keyword/PEPTIDE HYDROLASES, http://linkedlifedata.com/resource/pubmed/keyword/PHARMACOLOGY, http://linkedlifedata.com/resource/pubmed/keyword/PLASMINOGEN, http://linkedlifedata.com/resource/pubmed/keyword/RABBITS, http://linkedlifedata.com/resource/pubmed/keyword/SURFACE-ACTIVE AGENTS
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-74
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1965
pubmed:articleTitle
STUDIES ON THE TISSUE ACTIVATOR OF PLASMINOGEN. DISTRIBUTION OF ACTIVATOR AND PROTEOLYTIC ACTIVITY IN THE SUBCELLULAR FRACTIONS OF RABBIT KIDNEY.
pubmed:publicationType
Journal Article