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pubmed-article:14232193pubmed:abstractTextSulfaphenazole (Orisul), which had been reported to cause a convulsant syndrome in young European children, lowered the electroshock threshold in rats when administered in the form of tablets or suspension. This effect was not obtained with a sample of sulfaphenazole pure drug or with several other long-acting oral sulfonamide preparations, but was obtained with a mixture of impurities which had been found in the same lot of Orisul that had reportedly caused the convulsant syndrome. A change in the method of manufacture now provides a product which is free from these impurities.lld:pubmed
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pubmed-article:14232193pubmed:authorpubmed-author:ALLMARKM GMGlld:pubmed
pubmed-article:14232193pubmed:authorpubmed-author:RICHW EWElld:pubmed
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pubmed-article:14232193pubmed:dateRevised2010-6-22lld:pubmed
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pubmed-article:14232193pubmed:articleTitleSTIMULANT EFFECTS OF A SULFONAMIDE PREPARATION, SULFAPHENAZOLE, ON THE CENTRAL NERVOUS SYSTEM IN RATS.lld:pubmed
pubmed-article:14232193pubmed:publicationTypeJournal Articlelld:pubmed