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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-12-17
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pubmed:databankReference |
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pubmed:abstractText |
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/discs large 1 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/postsynaptic density proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
929-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1419001-Amino Acid Sequence,
pubmed-meshheading:1419001-Animals,
pubmed-meshheading:1419001-Base Sequence,
pubmed-meshheading:1419001-Brain,
pubmed-meshheading:1419001-Brain Chemistry,
pubmed-meshheading:1419001-DNA,
pubmed-meshheading:1419001-Dendrites,
pubmed-meshheading:1419001-Drosophila Proteins,
pubmed-meshheading:1419001-Gene Expression,
pubmed-meshheading:1419001-Insect Hormones,
pubmed-meshheading:1419001-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:1419001-Membrane Proteins,
pubmed-meshheading:1419001-Molecular Sequence Data,
pubmed-meshheading:1419001-Nerve Tissue Proteins,
pubmed-meshheading:1419001-RNA, Messenger,
pubmed-meshheading:1419001-Rats,
pubmed-meshheading:1419001-Sequence Homology, Amino Acid,
pubmed-meshheading:1419001-Synapses,
pubmed-meshheading:1419001-Tissue Distribution,
pubmed-meshheading:1419001-Tumor Suppressor Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.
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pubmed:affiliation |
Division of Biology, California Institute of Technology, Pasadena 91125.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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