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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1992-10-26
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pubmed:abstractText |
Experimental infection of animals with Histoplasma capsulatum caused a massive macrophage infiltration into the spleen and induced the production of tumor necrosis factor alpha (TNF-alpha) locally. The cytokine was also produced in vitro by peritoneal exudate macrophages exposed to a large inoculum of yeast cells. Depletion of the cytokine by injection of polyclonal sheep anti-TNF-alpha antibody was detrimental to sublethally infected mice. Fungous burdens in the spleens of TNF-alpha-depleted mice were higher than they were in the infected control mice at days 2, 7, and 9 after infection, and the antibody-treated animals succumbed to the infection. Histopathological study of spleen sections revealed that splenic macrophages were not able to control proliferation of intracellular yeasts as a result of TNF-alpha depletion. It seems that TNF-alpha plays a role in early activation of splenic macrophages which is important in controlling the outcome of an infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-1900461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-1937779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2112157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2113160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2115543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2201176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2205576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2230264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2335376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2499625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2501793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2509369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2509559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2559307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2584936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2657427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2667356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2731976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2754393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2785886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2789107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-2971759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3052281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3104206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3108447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3138177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3141092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3163717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3171821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3258346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3306918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3392416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3492537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3525677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-3932579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-5154897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-6134775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-6193516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-6452707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-7308288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1398934-870432
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4230-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1398934-Animals,
pubmed-meshheading:1398934-Histoplasmosis,
pubmed-meshheading:1398934-Macrophage Activation,
pubmed-meshheading:1398934-Macrophages,
pubmed-meshheading:1398934-Male,
pubmed-meshheading:1398934-Mice,
pubmed-meshheading:1398934-Mice, Inbred C57BL,
pubmed-meshheading:1398934-Recombinant Proteins,
pubmed-meshheading:1398934-Spleen,
pubmed-meshheading:1398934-Tumor Necrosis Factor-alpha
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pubmed:year |
1992
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pubmed:articleTitle |
Early activation of splenic macrophages by tumor necrosis factor alpha is important in determining the outcome of experimental histoplasmosis in mice.
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pubmed:affiliation |
Department of Microbiology and Immunology, UCLA School of Medicine 90024.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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