| pubmed-article:1397013 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1397013 | lifeskim:mentions | umls-concept:C1882561 | lld:lifeskim |
| pubmed-article:1397013 | lifeskim:mentions | umls-concept:C0012022 | lld:lifeskim |
| pubmed-article:1397013 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1397013 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1397013 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1397013 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1397013 | lifeskim:mentions | umls-concept:C0443254 | lld:lifeskim |
| pubmed-article:1397013 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1397013 | pubmed:dateCreated | 1992-11-13 | lld:pubmed |
| pubmed-article:1397013 | pubmed:abstractText | Diazoxide provoked concentration-dependent and endothelium-independent relaxations of the mechanical responses evoked by low concentrations of KCl. Glibenclamide, tolbutamide and tetraethylammonium shifted the concentration-response curve for diazoxide to the right. The drug also caused a dose-dependent stimulation of 86Rb outflow which was inhibited by glibenclamide and tolbutamide. Diazoxide (10(-4) and 10(-3) M) inhibited the contractions elicited by 10(-1) M K+ and provoked a concentration-dependent reduction in the contractile responses to Ca2+. Diazoxide also reduced the KCl (8 x 10(-2) M)-induced increase in 45Ca outflow. These data indicate that the vasorelaxant properties of diazoxide are probably related to an inhibition of Ca2+ entry into smooth muscle cells. The reduction in Ca2+ entry appears to result from K+ channel activation. At high concentrations, diazoxide also exhibited antagonistic actions on voltage-sensitive Ca2+ channels. | lld:pubmed |
| pubmed-article:1397013 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1397013 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1397013 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1397013 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1397013 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1397013 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1397013 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1397013 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1397013 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:1397013 | pubmed:author | pubmed-author:FontaineJJ | lld:pubmed |
| pubmed-article:1397013 | pubmed:author | pubmed-author:HerchuelzAA | lld:pubmed |
| pubmed-article:1397013 | pubmed:author | pubmed-author:BerkenboomGG | lld:pubmed |
| pubmed-article:1397013 | pubmed:author | pubmed-author:LebrunPP | lld:pubmed |
| pubmed-article:1397013 | pubmed:author | pubmed-author:FangZ YZY | lld:pubmed |
| pubmed-article:1397013 | pubmed:author | pubmed-author:AntoineM HMH | lld:pubmed |
| pubmed-article:1397013 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1397013 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:1397013 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:1397013 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1397013 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1397013 | pubmed:pagination | 299-306 | lld:pubmed |
| pubmed-article:1397013 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1397013 | pubmed:meshHeading | pubmed-meshheading:1397013-... | lld:pubmed |
| pubmed-article:1397013 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1397013 | pubmed:articleTitle | Mechanical and ionic response of rat aorta to diazoxide. | lld:pubmed |
| pubmed-article:1397013 | pubmed:affiliation | Laboratory of Pharmacology, Brussels Free University, Faculty of Medicine and Pharmacy, Belgium. | lld:pubmed |
| pubmed-article:1397013 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1397013 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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