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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-11-13
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pubmed:abstractText |
Diazoxide provoked concentration-dependent and endothelium-independent relaxations of the mechanical responses evoked by low concentrations of KCl. Glibenclamide, tolbutamide and tetraethylammonium shifted the concentration-response curve for diazoxide to the right. The drug also caused a dose-dependent stimulation of 86Rb outflow which was inhibited by glibenclamide and tolbutamide. Diazoxide (10(-4) and 10(-3) M) inhibited the contractions elicited by 10(-1) M K+ and provoked a concentration-dependent reduction in the contractile responses to Ca2+. Diazoxide also reduced the KCl (8 x 10(-2) M)-induced increase in 45Ca outflow. These data indicate that the vasorelaxant properties of diazoxide are probably related to an inhibition of Ca2+ entry into smooth muscle cells. The reduction in Ca2+ entry appears to result from K+ channel activation. At high concentrations, diazoxide also exhibited antagonistic actions on voltage-sensitive Ca2+ channels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
216
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-306
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1397013-Animals,
pubmed-meshheading:1397013-Aorta,
pubmed-meshheading:1397013-Calcium,
pubmed-meshheading:1397013-Calcium Radioisotopes,
pubmed-meshheading:1397013-Diazoxide,
pubmed-meshheading:1397013-Endothelium, Vascular,
pubmed-meshheading:1397013-Hypoglycemia,
pubmed-meshheading:1397013-Muscle, Smooth, Vascular,
pubmed-meshheading:1397013-Muscle Contraction,
pubmed-meshheading:1397013-Potassium Channels,
pubmed-meshheading:1397013-Potassium Chloride,
pubmed-meshheading:1397013-Rats,
pubmed-meshheading:1397013-Rats, Wistar,
pubmed-meshheading:1397013-Rubidium Radioisotopes,
pubmed-meshheading:1397013-Sulfonylurea Compounds,
pubmed-meshheading:1397013-Tetraethylammonium,
pubmed-meshheading:1397013-Tetraethylammonium Compounds
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pubmed:year |
1992
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pubmed:articleTitle |
Mechanical and ionic response of rat aorta to diazoxide.
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pubmed:affiliation |
Laboratory of Pharmacology, Brussels Free University, Faculty of Medicine and Pharmacy, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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