| pubmed-article:1385520 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0596902 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C1637379 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1385520 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1385520 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1385520 | pubmed:dateCreated | 1992-12-8 | lld:pubmed |
| pubmed-article:1385520 | pubmed:abstractText | Transporter in Ag processing-1 (TAP-1, previously called PSF-1 or Ring-4) is an MHC-encoded gene product that is required for efficient association of intracellular peptide Ag with nascent HLA class I H chain and beta 2-microglobulin, thereby permitting assembly and normal surface expression of the class I molecules. TAP-1 is thought to function as a component of a transmembrane pump, that transports cytoplasmically-derived peptides into the lumen of the endoplasmic reticulum where class I molecules assemble. Synthesis and expression of HLA class I molecules is increased in human endothelial cells by IFN-beta, IFN-gamma, and TNF. We report these same cytokines increase TAP-1 expression. As with class I, TAP-1 is also synergistically increased by combinations of TNF with IFN. Interestingly, cytokine-induced increases in TAP-1 mRNA are markedly more rapid than increases in class I mRNA. This rapid increase in TAP-1 mRNA is reflected in a rapid increase in TAP-1 protein. These results demonstrate that TAP-1 synthesis and class I synthesis are regulated in parallel. The rapidity of the cytokine response of TAP-1 compared to class I further suggests that the constitutive level of TAP-1 expression in endothelial cells is not sufficient to support inducible increases in class I expression. | lld:pubmed |
| pubmed-article:1385520 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1385520 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1385520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385520 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1385520 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1385520 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1385520 | pubmed:author | pubmed-author:SpierWW | lld:pubmed |
| pubmed-article:1385520 | pubmed:author | pubmed-author:PoberJ SJS | lld:pubmed |
| pubmed-article:1385520 | pubmed:author | pubmed-author:CresswellPP | lld:pubmed |
| pubmed-article:1385520 | pubmed:author | pubmed-author:JohnsonD RDR | lld:pubmed |
| pubmed-article:1385520 | pubmed:author | pubmed-author:ArnoldDD | lld:pubmed |
| pubmed-article:1385520 | pubmed:author | pubmed-author:EppersonD EDE | lld:pubmed |
| pubmed-article:1385520 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1385520 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1385520 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:1385520 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1385520 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1385520 | pubmed:pagination | 3297-301 | lld:pubmed |
| pubmed-article:1385520 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:meshHeading | pubmed-meshheading:1385520-... | lld:pubmed |
| pubmed-article:1385520 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1385520 | pubmed:articleTitle | Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. | lld:pubmed |
| pubmed-article:1385520 | pubmed:affiliation | Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510. | lld:pubmed |
| pubmed-article:1385520 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1385520 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1385520 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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