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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-10-30
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pubmed:abstractText |
We demonstrated that tumour necrosis factor alpha (TNF-alpha) and interleukin 4 (IL-4) increased endothelial cell (EC) adhesiveness for peripheral blood lymphocytes (PBL) by promoting transcription and protein synthesis. The different kinetics observed with TNF-alpha and IL-4 suggest the involvement of different adhesion molecules. Blocking adhesion assays and immunofluorescence analysis showed that PBL adhesion to endothelial cells involves different pair adhesion molecules. Whereas IL-4 promoted an LFA-1-dependent/ICAM-1-independent adhesion pathway on EC, TNF-alpha stimulated an LFA-1-dependent/ICAM-1-dependent adhesion pathway on EC. In contrast, VLA-4/VCAM-1 molecules were involved in PBL adhesion both to IL-4 and to TNF-alpha-stimulated EC. Finally, we found that a CD2-dependent/LFA-3-independent adhesion pathway was mainly involved in IL-4-stimulated EC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD58,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Dactinomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Very Late Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0300-9475
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
575-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1384114-Antigens, CD,
pubmed-meshheading:1384114-Antigens, CD2,
pubmed-meshheading:1384114-Antigens, CD58,
pubmed-meshheading:1384114-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1384114-Cell Adhesion,
pubmed-meshheading:1384114-Cell Adhesion Molecules,
pubmed-meshheading:1384114-Cells, Cultured,
pubmed-meshheading:1384114-Cycloheximide,
pubmed-meshheading:1384114-Dactinomycin,
pubmed-meshheading:1384114-Endothelium, Vascular,
pubmed-meshheading:1384114-Humans,
pubmed-meshheading:1384114-Interleukin-4,
pubmed-meshheading:1384114-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:1384114-Lymphocytes,
pubmed-meshheading:1384114-Membrane Glycoproteins,
pubmed-meshheading:1384114-Receptors, Immunologic,
pubmed-meshheading:1384114-Receptors, Very Late Antigen,
pubmed-meshheading:1384114-Tumor Necrosis Factor-alpha,
pubmed-meshheading:1384114-Vascular Cell Adhesion Molecule-1
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pubmed:year |
1992
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pubmed:articleTitle |
Interleukin 4 and tumour necrosis factor alpha induce different adhesion pathways in endothelial cells for the binding of peripheral blood lymphocytes.
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pubmed:affiliation |
Laboratoire d'Immunologie, CHU Bretonneau, Université de Tours, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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