Linked Life Data

13826481

Source:http://linkedlifedata.com/resource/pubmed/id/13826481

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1960-12-1
pubmed:abstractText
The demonstration of immunological differences between poliovirus strains of any one type is a valuable procedure in epidemiological research as it may allow a virus strain to be identified as derived from or unrelated to a given possible source of infection. It is obviously of particular importance in connexion with live poliovirus vaccination campaigns. Both kinetic tests and conventional neutralization and complement-fixation techniques have been used to this end, the former involving a more complicated test procedure and the latter demanding greater nicety in the pre-standardization of reagents. The present paper reports on attempts to establish a simplified technique.Neutralization titres of sera obtained by immunization of guinea-pigs with three strains of type 1 poliovirus (including one isolated from a patient in the 1958-59 epidemic in Léopoldville described in the two preceding papers) indicated a degree of strain specificity sufficient to permit the design of a simple screening method for the purpose of a rough immunological classification.Preliminary observations on isolates from persons fed attenuated virus indicate that antigenic changes may occur in the course of multiplication of the virus in the human intestinal tract.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:status
MEDLINE
pubmed:issn
0042-9686
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-42
pubmed:dateRevised
2010-10-26
pubmed:meshHeading
pubmed:year
1960
pubmed:articleTitle
Immunological strain specificity within type 1 poliovirus.
pubmed:publicationType
Journal Article