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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1992-8-10
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pubmed:abstractText |
Expression of human c-kit proto-oncogene and interleukin-7 receptor (IL-7R) in acute lymphoblastic leukemia (ALL) cells expressing CD7 was examined by Northern-blot analysis and reversed transcription polymerase chain reaction (RT-PCR) assay in relation to the phenotypes. Leukemic cells from four out of 12 CD7+ ALL patients, all of which fulfilled the criteria of ALL in the FAB classification, expressed c-kit genes. Surface CD3 (sCD3) was absent in all of these cases, while cytoplasmic CD3 (cCD3) was found in the two sCD3- cases. CD3 epsilon transcripts were detected in one of the sCD3- cCD3- cases. IL-7R genes were transcribed in the three cases with c-kit gene expression. In addition, there was a good correlation between c-kit gene expression and myeloid associated antigen CD13 positivity of the leukemic cells. None of the patients with c-kit gene expression had mediastinal tumor. Our results show that leukemic cells in a proportion of CD7+ ALL express receptors for cytokines that are secreted by bone marrow stromal cells. Ligands for c-kit genes and IL-7 could play an important role for the regulation of proliferation and differentiation of T-cell progenitors in bone marrow.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD13,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD7,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:geneSymbol |
CD3&egr;,
IL7R,
c-kit
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
662-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1378163-Antigens, CD,
pubmed-meshheading:1378163-Antigens, CD13,
pubmed-meshheading:1378163-Antigens, CD3,
pubmed-meshheading:1378163-Antigens, CD7,
pubmed-meshheading:1378163-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:1378163-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1378163-Gene Expression,
pubmed-meshheading:1378163-Genes,
pubmed-meshheading:1378163-Humans,
pubmed-meshheading:1378163-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:1378163-Proto-Oncogene Proteins,
pubmed-meshheading:1378163-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:1378163-RNA, Messenger,
pubmed-meshheading:1378163-Receptors, Antigen, T-Cell,
pubmed-meshheading:1378163-Receptors, Immunologic,
pubmed-meshheading:1378163-Receptors, Interleukin-7
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pubmed:year |
1992
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pubmed:articleTitle |
c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13.
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pubmed:affiliation |
Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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