|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1993-2-4
|
|
pubmed:abstractText |
Ammonium bituminosulphonate (Ichthyol) inhibits 5-lipoxygenase activity in human polymorphonuclear neutrophils. The inhibition is dose-dependent and occurs at non-cytotoxic concentrations of the drug. This results in a decreased release of Leukotriene B4 from polymorphonuclear neutrophils. Furthermore, when applied to the ear skin of AB/Bln mice pretreated with croton oil, Ichthyol reduces the inflammatory reaction.
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|
pubmed:language |
ger
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0017-8470
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
772-4
|
|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
pubmed-meshheading:1361926-Animals,
pubmed-meshheading:1361926-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:1361926-Arachidonic Acid,
pubmed-meshheading:1361926-Croton Oil,
pubmed-meshheading:1361926-Dermatitis,
pubmed-meshheading:1361926-Dermatologic Agents,
pubmed-meshheading:1361926-Leukotriene B4,
pubmed-meshheading:1361926-Lipoxygenase Inhibitors,
pubmed-meshheading:1361926-Male,
pubmed-meshheading:1361926-Mice,
pubmed-meshheading:1361926-Mice, Inbred Strains,
pubmed-meshheading:1361926-Neutrophils
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|
pubmed:year |
1992
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|
pubmed:articleTitle |
[Ammonium bituminosulfonate (Ichthyol). Anti-inflammatory effect and inhibition of the 5-lipoxygenase enzyme].
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|
pubmed:affiliation |
Dermatologische Klinik und Poliklinik Universität Rostock.
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|
pubmed:publicationType |
Journal Article,
English Abstract
|
