Linked Life Data

1352710

Source:http://linkedlifedata.com/resource/pubmed/id/1352710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-8-20
pubmed:abstractText
Some B-cell neoplasms, including hairy cell leukemia (HCL), lack expression of the adhesion molecule leukocyte function antigen-1 (LFA-1/CD11a). Additionally, HCL cells express relatively low amounts of intercellular adhesion molecule-1 (ICAM-1/CD54) and may therefore be an inappropriate target for recognition by T cells or lymphokine-activated killer (LAK) cells. We tested whether these molecules were inducible on HCL cells and if induction would lead to enhanced susceptibility to lysis by LAK cells or cytolytic T cells. CD11a expression was induced by incubation with interferon-alpha (IFN-alpha) or interleukin-4. CD54 was induced by culturing the cells irrespectively of the addition of cytokines. Expression of CD11a and CD54 did not enhance susceptibility to either autologous or allogeneous LAK cells. However, induction of these adhesion molecules was accompanied by enhanced susceptibility to lysis by cytotoxic T lymphocyte clones. This lysis could be reversed by the addition of anti-CD11a and anti-CD54 antibodies. Finally, we monitored the expression of CD11a and CD54 on HCL cells from patients during IFN-alpha therapy. In one of four patients monitored, we observed rapid in vivo induction of CD11a and CD54 on the leukemic cells during IFN-alpha therapy. These studies provide a model for studying immunosurveillance in HCL.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
478-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1352710-Antigens, CD, pubmed-meshheading:1352710-B-Lymphocytes, pubmed-meshheading:1352710-Cell Adhesion Molecules, pubmed-meshheading:1352710-Cells, Cultured, pubmed-meshheading:1352710-Cytotoxicity, Immunologic, pubmed-meshheading:1352710-Flow Cytometry, pubmed-meshheading:1352710-Humans, pubmed-meshheading:1352710-Intercellular Adhesion Molecule-1, pubmed-meshheading:1352710-Interferon-alpha, pubmed-meshheading:1352710-Interleukin-4, pubmed-meshheading:1352710-Killer Cells, Lymphokine-Activated, pubmed-meshheading:1352710-Leukemia, Hairy Cell, pubmed-meshheading:1352710-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:1352710-Spleen, pubmed-meshheading:1352710-Splenectomy, pubmed-meshheading:1352710-T-Lymphocytes, pubmed-meshheading:1352710-T-Lymphocytes, Cytotoxic
pubmed:year
1992
pubmed:articleTitle
Induction of CD11a/leukocyte function antigen-1 and CD54/intercellular adhesion molecule-1 on hairy cell leukemia cells is accompanied by enhanced susceptibility to T-cell but not lymphokine-activated killer-cell cytotoxicity.
pubmed:affiliation
Department of Hematology, University Medical Center, Leiden, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't