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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-8-7
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pubmed:databankReference |
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pubmed:abstractText |
We here report the existence of 6 additional isoforms of the NMDA receptor generated via alternative splicing by molecular analysis of cDNA clones isolated from a rat forebrain cDNA library. These isoforms possess the structures with an insertion at the extracellular amino-terminal region or deletions at two different extracellular carboxyl-terminal regions, or those formed by combinations of the above insertion and deletions. One of the deletions results in the generation of a new carboxyl-terminal sequence. All these isoforms possess the ability to induce electrophysiological responses to NMDA and respond to various antagonists selective to the NMDA receptor in the Xenopus oocyte expression system. In addition, a truncated form of the NMDA receptor also exists that contains only the extreme amino-terminal sequence of this protein molecule. These data indicate that the NMDA receptor consists of heterogeneous molecules that differ in the extracellular sequence of the amino- and carboxyl-terminal regions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/3-(2-carboxypiperazin-4-yl)propyl-1-...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Kynurenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
826-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1352681-2-Amino-5-phosphonovalerate,
pubmed-meshheading:1352681-Amino Acid Sequence,
pubmed-meshheading:1352681-Animals,
pubmed-meshheading:1352681-Base Sequence,
pubmed-meshheading:1352681-Chromosome Deletion,
pubmed-meshheading:1352681-Cloning, Molecular,
pubmed-meshheading:1352681-DNA,
pubmed-meshheading:1352681-Dizocilpine Maleate,
pubmed-meshheading:1352681-Gene Library,
pubmed-meshheading:1352681-Kynurenic Acid,
pubmed-meshheading:1352681-Molecular Sequence Data,
pubmed-meshheading:1352681-N-Methylaspartate,
pubmed-meshheading:1352681-Oocytes,
pubmed-meshheading:1352681-Piperazines,
pubmed-meshheading:1352681-Prosencephalon,
pubmed-meshheading:1352681-RNA, Messenger,
pubmed-meshheading:1352681-RNA Splicing,
pubmed-meshheading:1352681-Rats,
pubmed-meshheading:1352681-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:1352681-Restriction Mapping,
pubmed-meshheading:1352681-Xenopus
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pubmed:year |
1992
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pubmed:articleTitle |
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
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pubmed:affiliation |
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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