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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0015219,
umls-concept:C0026809,
umls-concept:C0027540,
umls-concept:C0077503,
umls-concept:C0087111,
umls-concept:C0237477,
umls-concept:C0812246,
umls-concept:C0971858,
umls-concept:C1456820,
umls-concept:C1521761,
umls-concept:C1749467
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pubmed:issue |
4
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pubmed:dateCreated |
1993-3-9
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pubmed:abstractText |
Immunization of DBA/1 mice with type II collagen within complete Freund's adjuvant leads to arthritis, lasting more than 3 months. Injection of anti-tumour necrosis factor (TNF) IgG, 2 and 3 weeks after immunization prevented the development of arthritis in the following months. This treatment had no effect when started 2 months after induction of the disease. A soluble form of the human recombinant TNF receptor type-beta (rsTNFR-beta), continuously infused at a rate of 20 micrograms/day during the second and third week after immunization, also had a long-term protective effect. Anti-TNF antibody had no effect upon the production of anti-type II collagen antibodies. These results indicate that TNF is critically involved in an early phase of this arthritis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-1655744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-1657617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-1717618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-1900080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-2121890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-2458872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-2475571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-2493048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-2540776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-2569055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3049913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3053308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3092113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3102073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3316469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3511389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3736671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3744440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3928802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3933111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-3934318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-6303388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-6792316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1337334-6997383
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
510-4
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1337334-Animals,
pubmed-meshheading:1337334-Arthritis,
pubmed-meshheading:1337334-Autoantibodies,
pubmed-meshheading:1337334-Collagen,
pubmed-meshheading:1337334-Foot,
pubmed-meshheading:1337334-Immunoglobulin G,
pubmed-meshheading:1337334-Male,
pubmed-meshheading:1337334-Mice,
pubmed-meshheading:1337334-Mice, Inbred DBA,
pubmed-meshheading:1337334-RNA, Messenger,
pubmed-meshheading:1337334-Receptors, Cell Surface,
pubmed-meshheading:1337334-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:1337334-Recombinant Proteins,
pubmed-meshheading:1337334-Tumor Necrosis Factor-alpha
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pubmed:year |
1992
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pubmed:articleTitle |
Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.
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pubmed:affiliation |
Department of Pathology, University of Geneva, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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