Linked Life Data

1324274

Source:http://linkedlifedata.com/resource/pubmed/id/1324274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1992-9-22
pubmed:abstractText
The renin-angiotensin-aldosterone system is activated by diuretics and involved in the diuretic resistance of cirrhotic patients with ascites and oedema. In previous studies relatively high doses of captopril (25-400 mg daily) were unsuccessful in promoting diuresis and natriuresis in these patients. We analyzed the efficacy of a low dose of captopril in eight patients with massive ascites resistant to therapy of salt/fluid restriction and increasing doses of spironolactone and furosemide. Mean duration of diuretic use was 73 days (range 7-240 days). After at least 3 days of observation on 80 mg furosemide and 100 mg spironolactone only, captopril was added. Four out of eight patients responded with an increase in natriuresis and diuresis; daily dose of captopril was 20.6 mg in responders and 26.5 mg in non-responders. After the addition of captopril the mean weight change was -7.5 kg in responders and +0.25 kg in non-responders. Mean urinary sodium output in responders increased from 72.8 (S.D. = 35.2) to 128.5 (63.5) mmol within 10 days. Increased diuresis in responders made diuretic reduction necessary: mean furosemide from 80 to 53.3 mg, and mean spironolactone from 100 to 68.1 mg. Creatinine clearances remained stable. High levels of plasma renin activity, plasma aldosterone and angiotensin-II were found in all patients. Non-responders showed more severe hyponatremia and higher vasopressin levels. Natriuretic atrial factor (NAF) was in the upper-normal range or slightly elevated in both groups. In non-responders we noticed low levels of cGMP in 24-h urine, compared with responders.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0168-8278
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1324274-Adult, pubmed-meshheading:1324274-Aged, pubmed-meshheading:1324274-Aldosterone, pubmed-meshheading:1324274-Angiotensin II, pubmed-meshheading:1324274-Atrial Natriuretic Factor, pubmed-meshheading:1324274-Captopril, pubmed-meshheading:1324274-Creatinine, pubmed-meshheading:1324274-Cyclic GMP, pubmed-meshheading:1324274-Diuresis, pubmed-meshheading:1324274-Dose-Response Relationship, Drug, pubmed-meshheading:1324274-Drug Therapy, Combination, pubmed-meshheading:1324274-Female, pubmed-meshheading:1324274-Follow-Up Studies, pubmed-meshheading:1324274-Furosemide, pubmed-meshheading:1324274-Humans, pubmed-meshheading:1324274-Kidney, pubmed-meshheading:1324274-Liver, pubmed-meshheading:1324274-Liver Cirrhosis, pubmed-meshheading:1324274-Male, pubmed-meshheading:1324274-Middle Aged, pubmed-meshheading:1324274-Renal Dialysis, pubmed-meshheading:1324274-Renin, pubmed-meshheading:1324274-Sodium, pubmed-meshheading:1324274-Spironolactone
pubmed:year
1992
pubmed:articleTitle
Efficacy of low-dose captopril in addition to furosemide and spironolactone in patients with decompensated liver disease during blunted diuresis.
pubmed:affiliation
Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't