Linked Life Data

1322308

Source:http://linkedlifedata.com/resource/pubmed/id/1322308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-8-28
pubmed:abstractText
We have demonstrated that the aminosteroid, U-73122 (1-(6-([17 beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino)hexyl)-1H-pyrrole- 2,5-dione) blocks agonist induced down-regulation of neurotensin receptors in murine neuroblastoma clone N1E-115 cells. U-73122 is known to inhibit polyphosphoinositide hydrolysis by affecting the coupling of GTP-binding proteins. Our results may indicate that GTP-binding proteins play a role in the mechanism of down-regulation of the neurotensin receptor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
226
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Block of neurotensin receptor down-regulation by an aminosteroid in N1E-115 cells.
pubmed:affiliation
Mayo Foundation, Jacksonville, FL 32224.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't