| pubmed-article:1319243 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1319243 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:1319243 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1319243 | lifeskim:mentions | umls-concept:C1518294 | lld:lifeskim |
| pubmed-article:1319243 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1319243 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1319243 | pubmed:dateCreated | 1992-7-28 | lld:pubmed |
| pubmed-article:1319243 | pubmed:abstractText | Expression of the mouse beta-PDGF receptor by gene transfer confers PDGF-dependent and reversible neuronal differentiation of PC12 pheochromocytoma cells similar to that observed in response to NGF and basic FGF. A common property of the PDGF, NGF, and basic FGF-induced differentiation response is the requirement for constant exposure of cells to the growth factor. To test the hypothesis that a persistent level of growth factor receptor signaling is required for the maintenance of the neuronal phenotype, we examined the regulation of the serine/threonine-specific MAP kinases after either short- (10 min) or long-term (24 h) stimulation with growth factors. Mono Q FPLC resolved two peaks of growth factor-stimulated MAP kinase activity that coeluted with tyrosine phosphorylated 41- and 43-kDa polypeptides. MAP kinase activity was markedly stimulated (approximately 30-fold) within 5 min of exposure to several growth factors (PDGF, NGF, basic FGF, EGF, and IGF-I), but was persistently maintained at 10-fold above basal activity after 24 h only by the growth factors that also induce PC12 cell differentiation (PDGF, NGF, and basic FGF). Thus the beta-PDGF receptor is in a subset of tyrosine kinase-encoded growth factor receptors that are capable of maintaining continuous signals required for differentiation of PC12 cells. These signals include the constitutive activation of cytoplasmic serine/threonine protein kinases. | lld:pubmed |
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| pubmed-article:1319243 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1319243 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1319243 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1319243 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1319243 | pubmed:month | May | lld:pubmed |
| pubmed-article:1319243 | pubmed:issn | 1059-1524 | lld:pubmed |
| pubmed-article:1319243 | pubmed:author | pubmed-author:JohnsonG LGL | lld:pubmed |
| pubmed-article:1319243 | pubmed:author | pubmed-author:HeasleyL ELE | lld:pubmed |
| pubmed-article:1319243 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1319243 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:1319243 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1319243 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1319243 | pubmed:pagination | 545-53 | lld:pubmed |
| pubmed-article:1319243 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1319243 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1319243 | pubmed:articleTitle | The beta-PDGF receptor induces neuronal differentiation of PC12 cells. | lld:pubmed |
| pubmed-article:1319243 | pubmed:affiliation | Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206. | lld:pubmed |
| pubmed-article:1319243 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1319243 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1319243 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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