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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1992-7-10
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pubmed:abstractText |
We have asked how the human cytomegalovirus major immediate-early 1 (IE1) and 2 (IE2) proteins act to transactivate heterologous cellular and viral promoters. Here we show that transactivation of the human immunodeficiency virus long terminal repeat and the 70,000-molecular-weight heat shock protein (hsp70) promoter by IE1 is TATA box independent and that the IE1 protein does not interact directly with the TATA box-binding factor TFIID. Conversely, transactivation of these promoters by IE2 is TATA box dependent and a direct interaction between IE2 and TFIID occurs, suggesting that IE2 transactivation is mediated through interaction with TFIID.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-1310765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-1645794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-1647074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-1833071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2001592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2142019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2157038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2157043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2177717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2193231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2194289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2505081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2521923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2536844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2542583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2667136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2823252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2830675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2830987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2830991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2831379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2843425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2986374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-2999423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-3002824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-3020431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-3047011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-3047590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-3061875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-3340539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-6286831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1318414-6960240
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IE1 protein, cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/IE2 protein, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor TFIID,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/UL115 protein, Human herpesvirus 5,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein O, cytomegalovirus
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4452-6
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1318414-Cells, Cultured,
pubmed-meshheading:1318414-Cytomegalovirus,
pubmed-meshheading:1318414-HIV Long Terminal Repeat,
pubmed-meshheading:1318414-HIV-1,
pubmed-meshheading:1318414-Heat-Shock Proteins,
pubmed-meshheading:1318414-Immediate-Early Proteins,
pubmed-meshheading:1318414-Membrane Glycoproteins,
pubmed-meshheading:1318414-Promoter Regions, Genetic,
pubmed-meshheading:1318414-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1318414-TATA Box,
pubmed-meshheading:1318414-Trans-Activators,
pubmed-meshheading:1318414-Transcription Factor TFIID,
pubmed-meshheading:1318414-Transcription Factors,
pubmed-meshheading:1318414-Transcriptional Activation,
pubmed-meshheading:1318414-Viral Envelope Proteins,
pubmed-meshheading:1318414-Viral Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.
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pubmed:affiliation |
Wellcome/CRC Institute, Cambridge, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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