|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1993-6-10
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1061-4036
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
1
|
|
pubmed:geneSymbol |
CDP,
cut,
gp91-phox
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
50-5
|
|
pubmed:dateRevised |
2008-9-13
|
|
pubmed:meshHeading |
pubmed-meshheading:1301999-Amino Acid Sequence,
pubmed-meshheading:1301999-Animals,
pubmed-meshheading:1301999-Base Sequence,
pubmed-meshheading:1301999-Cloning, Molecular,
pubmed-meshheading:1301999-DNA,
pubmed-meshheading:1301999-Drosophila,
pubmed-meshheading:1301999-Drosophila Proteins,
pubmed-meshheading:1301999-Gene Expression,
pubmed-meshheading:1301999-HeLa Cells,
pubmed-meshheading:1301999-Homeodomain Proteins,
pubmed-meshheading:1301999-Humans,
pubmed-meshheading:1301999-Molecular Sequence Data,
pubmed-meshheading:1301999-Nerve Tissue Proteins,
pubmed-meshheading:1301999-Nuclear Proteins,
pubmed-meshheading:1301999-Repressor Proteins,
pubmed-meshheading:1301999-Sequence Homology, Amino Acid,
pubmed-meshheading:1301999-Species Specificity,
pubmed-meshheading:1301999-Transcription Factors
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.
|
|
pubmed:affiliation |
Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
