Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-9-16
pubmed:abstractText
Our earlier investigations have demonstrated a critical difference in the efficacy of orally administered porcine compared to human or mouse insulin (no effect) in preventing type I diabetes in two distinct experimental models. Based on these findings one has to assume that certain insulins might not be suitable for the induction of oral 'tolerance'/bystander suppression, which might be one cause for recent failures in human oral antigen trials. Here we demonstrate that coupling to the non-toxic subunit of cholera toxin (CTB) can abolish these differences in efficacy between human and porcine insulin. As expected, an added benefit was the much smaller oral antigen dose required to induce CD4+ insulin-B specific regulatory cells that bystander-suppress autoaggressive responses. Mechanistically we found that uptake or transport of insulin-CTB conjugates in the gut occurs at least partially via binding to GM-1, which would explain the enhanced clinical efficacy. Both B chains bound well to major histocompatibility complex (MHC) class II, indicating comparable immunological potential once uptake and processing has occurred. Thus, our findings delineate a pathway to overcome issues in oral antigen choice for prevention of type I diabetes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10219652, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10411548, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10438916, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10480600, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10535448, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10549628, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10677519, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10950231, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-10990077, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11017150, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11032852, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11067957, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11078446, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11102776, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11160264, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11175852, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-11334483, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-12727928, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-1901764, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-1901765, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-1946445, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-1975260, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-2535860, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-2901002, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-7680493, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-7889411, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8050186, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8157979, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8290544, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8610972, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8777718, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8823297, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8939860, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-8984662, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9046967, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9091575, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9114038, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9200945, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9218748, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9588832, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9765468, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9788349, http://linkedlifedata.com/resource/pubmed/commentcorrection/12974752-9818541
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-45
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
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