|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0013126,
umls-concept:C0013138,
umls-concept:C0018866,
umls-concept:C0035820,
umls-concept:C0425087,
umls-concept:C0439097,
umls-concept:C0678544,
umls-concept:C1313915,
umls-concept:C1511938,
umls-concept:C1517080,
umls-concept:C1547348,
umls-concept:C1705241
|
|
pubmed:issue |
21
|
|
pubmed:dateCreated |
2003-9-16
|
|
pubmed:abstractText |
In Drosophila, a wave of differentiation progresses across the retinal field in response to signals from posterior cells. Hedgehog (Hh), Decapentaplegic (Dpp) and Notch (N) signaling all contribute. Clones of cells mutated for receptors and nuclear effectors of one, two or all three pathways were studied to define systematically the necessary and sufficient roles of each signal. Hh signaling alone was sufficient for progressive differentiation, acting through both the transcriptional activator Ci155 and the Ci75 repressor. In the absence of Ci, Dpp and Notch signaling together provided normal differentiation. Dpp alone sufficed for some differentiation, but Notch was not sufficient alone and acted only to enhance the effect of Dpp. Notch acted in part through downregulation of Hairy; Hh signaling downregulated Hairy independently of Notch. One feature of this signaling network is to limit Dpp signaling spatially to a range coincident with Hh.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/delta protein,
http://linkedlifedata.com/resource/pubmed/chemical/dpp protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/hairy protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/hairy protein, insect,
http://linkedlifedata.com/resource/pubmed/chemical/hedgehog protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0950-1991
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
130
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5229-39
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12954721-Animals,
pubmed-meshheading:12954721-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:12954721-Cell Differentiation,
pubmed-meshheading:12954721-Drosophila Proteins,
pubmed-meshheading:12954721-Drosophila melanogaster,
pubmed-meshheading:12954721-Gene Expression Regulation, Developmental,
pubmed-meshheading:12954721-Hedgehog Proteins,
pubmed-meshheading:12954721-Homeodomain Proteins,
pubmed-meshheading:12954721-Insect Proteins,
pubmed-meshheading:12954721-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12954721-Membrane Proteins,
pubmed-meshheading:12954721-Morphogenesis,
pubmed-meshheading:12954721-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:12954721-Receptors, Notch,
pubmed-meshheading:12954721-Repressor Proteins,
pubmed-meshheading:12954721-Signal Transduction,
pubmed-meshheading:12954721-Trans-Activators
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development.
|
|
pubmed:affiliation |
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
