rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021758,
umls-concept:C0030685,
umls-concept:C0282555,
umls-concept:C0391871,
umls-concept:C0678594,
umls-concept:C0680255,
umls-concept:C1042722,
umls-concept:C1283071,
umls-concept:C1456820,
umls-concept:C1514873,
umls-concept:C1963578
|
pubmed:issue |
19
|
pubmed:dateCreated |
2003-9-2
|
pubmed:abstractText |
The 80% aqueous acetone extract of the rhizomes of Alpinia galanga was found to inhibit release of beta-hexosaminidase, as a marker of antigen-IgE-mediated degranulation in RBL-2H3 cells. Nine known phenylpropanoids and p-hydroxybenzaldehyde were isolated from the extract. Among them, 1'S-1'-acetoxychavicol acetate and 1'S-1'-acetoxyeugenol acetate exhibited potent inhibitory activity with IC(50) values of 15 and 19 microM. From the effects of various related compounds, both the 1'- and 4-acetoxyl groups of 1'S-1'-acetoxychavicol acetate and 1'S-1'-acetoxyeugenol acetate were essential for their strong activity, and the 2'-3' double bond enhanced the activity. In addition, 1'S-1'-acetoxychavicol acetate and 1'S-1'-acetoxyeugenol acetate inhibited ear passive cutaneous anaphylaxis reactions in mice and the antigen-IgE-mediated TNF-alpha and IL-4 production, both of which participate in the late phase of type I allergic reactions, in RBL-2H3 cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0960-894X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3197-202
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12951092-Alpinia,
pubmed-meshheading:12951092-Animals,
pubmed-meshheading:12951092-Anti-Allergic Agents,
pubmed-meshheading:12951092-Cell Degranulation,
pubmed-meshheading:12951092-Cell Line, Tumor,
pubmed-meshheading:12951092-Interleukin-4,
pubmed-meshheading:12951092-Male,
pubmed-meshheading:12951092-Mast Cells,
pubmed-meshheading:12951092-Mice,
pubmed-meshheading:12951092-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:12951092-Phenylpropionates,
pubmed-meshheading:12951092-Plant Extracts,
pubmed-meshheading:12951092-Rats,
pubmed-meshheading:12951092-Rhizome,
pubmed-meshheading:12951092-Structure-Activity Relationship,
pubmed-meshheading:12951092-Tumor Necrosis Factor-alpha
|
pubmed:year |
2003
|
pubmed:articleTitle |
Antiallergic principles from Alpinia galanga: structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells.
|
pubmed:affiliation |
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|