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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-9-1
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pubmed:abstractText |
Type 1 diabetes mellitus (DM1) is frequently accompanied by thyroid autoimmunity (TAI). The aims of the present study were to estimate the prevalence of TAI and to determine the contribution of HLA-DQA1 and -DQB1 polymorphisms to TAI susceptibility among children with DM1. PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). HLA-DQA1 and -DQB1 were genotyped using PCR-SSP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0334-018X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
851-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12948297-Adolescent,
pubmed-meshheading:12948297-Alleles,
pubmed-meshheading:12948297-Autoantibodies,
pubmed-meshheading:12948297-Child,
pubmed-meshheading:12948297-Child, Preschool,
pubmed-meshheading:12948297-Diabetes Mellitus, Type 1,
pubmed-meshheading:12948297-Female,
pubmed-meshheading:12948297-HLA-DQ Antigens,
pubmed-meshheading:12948297-Histocompatibility Testing,
pubmed-meshheading:12948297-Humans,
pubmed-meshheading:12948297-Infant,
pubmed-meshheading:12948297-Male,
pubmed-meshheading:12948297-Phenotype,
pubmed-meshheading:12948297-Poland,
pubmed-meshheading:12948297-Polymorphism, Genetic,
pubmed-meshheading:12948297-Risk Assessment,
pubmed-meshheading:12948297-Thyroid Function Tests,
pubmed-meshheading:12948297-Thyroiditis, Autoimmune
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pubmed:articleTitle |
HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus.
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pubmed:affiliation |
2nd Department of Pediatrics, 2nd Medical School, Charles University, Prague, Czech Republic. Zdenek.Sumnik@Lfmotol.cuni.cz
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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